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2023-24 NR 577 final Exam Question 1-54 With 100% Correct Answer More likely to cause hypoglycemia Correct Ans.... Insulin, sulfonylureas, meglitinides, amylin analogues Less likley to cause hypoglycemia Correct Ans.... Incretin mimetics, metformin, thiazolidneidiones, dpp-4 inhibitors Biguanides Correct Ans.... metformin MOA of metformin Correct Ans.... enhance tissue responsiveness to insulin. They are also less likely to cause hypoglycemia and help tx insulin resistance. Metformin facilitates insulin uptake by peripheral tissue especially muscle and liver and decrease hepatic gluconeogenesis and basal glucose output thus lowering fasting glucose levels. Dosing of metformin Correct Ans.... Starting 500mg QD then after one week 500mg BID then rise slowly over 1-2 wks before your at max dose between 2000-2500mg/QD